Question

How does the nature of solvent and substituent of molecule affect the strength of the acid

Answer 1

First, we will focus on individual atoms, and think about trends associated with the position of an element on the periodic table. We’ll use as our first models the simple organic compounds ethane, methylamine, and ethanol, but the concepts apply equally to more complex biomolecules with the same functionalities, for example the side chains of the amino acids alanine (alkane), lysine (amine), and serine (alcohol).