Question

How does the selection process of b cell influence the development of central tolerance ?

Answer 1

Central tolerance, also known as negative selection, is the process of eliminating any developing T or B lymphocytes that are reactive to self.[1] Through elimination of autoreactive lymphocytes, tolerance ensures that the immune system does not attack self peptides.[2] Lymphocyte maturation (and central tolerance) occurs in primary lymphoid organs such as the bone marrow and the thymus. In mammals, B cells mature in the bone marrow and T cells mature in the thymus.[1]

Central tolerance is not perfect, so peripheral tolerance exists as a secondary mechanism to ensure that T and B cells are not self-reactive once they leave primary lymphoid organs.[3] Peripheral tolerance is distinct from central tolerance in that it occurs once developing immune cells exit primary lymphoid organs (the thymus and bone-marrow), prior to their export into the periphery.