How enzymes reduces the amount of activation energy
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Enzymes generally lower activation energy by reducing the energy needed for reactants to come together and react. For example:
Enzymes bring reactants together so they don’t have to expend energy moving about until they collide at random. Enzymes bind both reactant molecules (called the substrate), tightly and specifically, at a site on the enzyme molecule called the active site.
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The enzymes may create a charge distribution opposite to that of the transition state
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