How has biotechnology helped in improving life of Diabetic people
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Answered by
5
Answer:
Insulin from biotechnically modified bacteria help in improvement of diabetics life .
From them insulin can be obtained in large quantity
as they divide rapidly .
Insulin making Genes from human is introduced in gene of bacteria by this they start to produce insulin
Answered by
3
Answer:
- Insulin used for diabetes was earlier extracted from pancreas of slaughtered cattle and pigs.
- Insulin from an animal source, though caused some patients to develop allergy or other types of reactions to the foreign protein.
- Insulin consists of two short polypeptide chains: chain A and chain B, that are linked together by disulphide bridges.
- In mammals, including humans, insulin is synthesised as a pro-hormone (like a pro-enzyme, the pro-hormone also needs to be processed before it becomes a fully mature and functional hormone) which contains an extra stretch called the C peptide.
- This C peptide is not present in the mature insulin and is removed during maturation into insulin.
- The main challenge for production of insulin using rDNA techniques was getting insulin assembled into a mature form.
- In 1983, Eli Lilly an American company prepared two DNA sequences
- corresponding to A and B, chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains.
- Chains A and B were produced separately, extracted and combined by creating disulphide bonds to form human insulin.
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