Question

How Hepatitis C Takes Control

Answer 1

The hepatitis C virus shuts down the liver protein synthesis machinery and forces the resources of the infected cell to be diverted into production of viral proteins that will be used to make new virus. It does this by commandeering the cell’s ribosomes to its own mRNAs. Hepatitis C mRNAs do not have a 7-methyl guanosine cap at their 5ends. Instead they have internal ribosome entry sites (IRES), which are specific sequences to which the ribosomes bind tightly. The clamping of the ribosome to the IRES forces initiation of viral protein synthesis at the expense of host cell protein synthesis. Hepatitis C is a particularly nasty virus because infected people can go on to develop liver cancer, cirrhosis, and other chronic liver disease. In the United States alone, 10,000 people die per year from hepatitis C infection. It is hoped that drugs can be developed that will prevent the host ribosome from binding to the viral IRES and so halt the Viruses.

Answer 2

Do not inject drugs. If you do inject drugs, stop and get into a treatment program. If you can’t stop, never share needles, syringes, water, or “works”Do not share personal care items that might have blood on them (razors, toothbrushes)If you are a health care or public safety worker, follow universal blood/body fluid precautions and safely handle needles and other sharps

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