How high concentration of salt help in binding of dna to silica?
Answers
DNA separation by silica adsorption is a method of DNA separation that is based on DNA molecules binding to silica surfaces in the presence of certain salts and under certain pH conditions.
Conventional methods for DNA extraction, such as ethanol precipitation or preparations using commercial purification kits, cannot be integrated onto microchips because they require multiple hands-on processing steps. In addition, they also require large equipment and high volumes of reagents and samples. DNA extraction on microchips provides a fast, cost effective, and effective for high-throughput screening, which also has a very small footprint. This new method has useful applications for biosensors, lab on a chip devices, and other new technologies that require rapid, high quality DNA at minimal cost.[citation needed]