how is firstly neurone made or form in human body
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draws on both neuroscience and developmental biology to describe the cellular and molecular mechanisms by which complex nervous systems emerge during embryonic development and throughout life.
Some landmarks of embryonic neural development include the birth and differentiation of neurons from stem cellprecursors, the migration of immature neurons from their birthplaces in the embryo to their final positions, outgrowth of axonsfrom neurons and guidance of the motile growth cone through the embryo towards postsynaptic partners, the generation of synapses between these axons and their postsynaptic partners, the neuron pruning that occurs in adolescence, and finally the lifelong changes in synapses which are thought to underlie learning and memory.
Typically, these neurodevelopmental processes can be broadly divided into two classes: activity-independent mechanisms and activity-dependent mechanisms. Activity-independent mechanisms are generally believed to occur as hardwired processes determined by genetic programs played out within individual neurons. These include differentiation, migration and axon guidanceto their initial target areas. These processes are thought of as being independent of neural activity and sensory experience. Once axonsreach their target areas, activity-dependent mechanisms come into play. Neural activity and sensory experience will mediate formation of new synapses, as well as synaptic plasticity, which will be responsible for refinement of the nascent neural circuits.
Some landmarks of embryonic neural development include the birth and differentiation of neurons from stem cellprecursors, the migration of immature neurons from their birthplaces in the embryo to their final positions, outgrowth of axonsfrom neurons and guidance of the motile growth cone through the embryo towards postsynaptic partners, the generation of synapses between these axons and their postsynaptic partners, the neuron pruning that occurs in adolescence, and finally the lifelong changes in synapses which are thought to underlie learning and memory.
Typically, these neurodevelopmental processes can be broadly divided into two classes: activity-independent mechanisms and activity-dependent mechanisms. Activity-independent mechanisms are generally believed to occur as hardwired processes determined by genetic programs played out within individual neurons. These include differentiation, migration and axon guidanceto their initial target areas. These processes are thought of as being independent of neural activity and sensory experience. Once axonsreach their target areas, activity-dependent mechanisms come into play. Neural activity and sensory experience will mediate formation of new synapses, as well as synaptic plasticity, which will be responsible for refinement of the nascent neural circuits.
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