How is oxidation and reduction takes place simultaneously in the oxidative decarboxylation process of pyruvate?
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In a multistep reaction catalyzed by the enzyme pyruvate dehydrogenase, pyruvate is oxidized by NAD+, decarboxylated, and covalently linked to a molecule of co-enzyme A via a thioester bond. ... In addition, one molecule of NAD+ is reduced to NADH during this process per molecule of pyruvate oxidized.
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