How many naturals penicillins have been isolated so far ?
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How many naturals penicillins have been isolated so far
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First isolation and successful treatment
In 1928, Scottish biologist Alexander Fleming noticed a halo of inhibition of bacterial growth around a contaminant blue-green mold on a Staphylococcus plate culture. He concluded that the mold was releasing a substance that was inhibiting bacterial growth. He grew a pure culture of the mold and subsequently concentrated what he later named "penicillin". During the next twelve years, Fleming grew and distributed the original mold, which was eventually identified as Penicillium notatum (now known as Penicillium chrysogenum). He was unsuccessful in making a stable form of it for mass production.[19]
Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to treat sycosis (eruptions in beard follicles) with penicillin but was unsuccessful, probably because the drug did not penetrate deep enough. Moving on to ophthalmia neonatorum, a gonococcal infection in babies, he achieved the first cure on 25 November 1930. He cured four patients (one adult, the others infants) of eye infections, although a fifth patient was not so lucky.[20]
In 1928, Scottish biologist Alexander Fleming noticed a halo of inhibition of bacterial growth around a contaminant blue-green mold on a Staphylococcus plate culture. He concluded that the mold was releasing a substance that was inhibiting bacterial growth. He grew a pure culture of the mold and subsequently concentrated what he later named "penicillin". During the next twelve years, Fleming grew and distributed the original mold, which was eventually identified as Penicillium notatum (now known as Penicillium chrysogenum). He was unsuccessful in making a stable form of it for mass production.[19]
Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to treat sycosis (eruptions in beard follicles) with penicillin but was unsuccessful, probably because the drug did not penetrate deep enough. Moving on to ophthalmia neonatorum, a gonococcal infection in babies, he achieved the first cure on 25 November 1930. He cured four patients (one adult, the others infants) of eye infections, although a fifth patient was not so lucky.[20]
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