How much plant extract is used for solubility test?
Answers
I develop a water soluble powder for veterinary medicine which consits multivitamin, mineral and also plant powder-extract. The plant powder-extract are insoluble in water.
I've added some wetting agenst to improve the solubility, such as:
Silicon Dioxide Colloidal (Aerosil)
Sodium Lauryl Sulphate / SLS
and also alkalizing agent, meglumine.
When I added meglumine excessively, the final product were dissolved completly, but when I calculate the quantities and refers to the safety of ADI, it's not allowed to adding in that quantities...
I've tried to make wet granulation with mix the plant powder-extract with polysorbate 80 and oven it at 60 degres Celcius... the final product were perfectly dissolved, but the powder became harder and stone-like form...
If I was not oven it, then I just mixed that surfactant with another raw materials, the final product was still completely dissolved, but after 3 - 5 months it darken gradually and became wet...