how nacl removed from interstitium
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Answer:
Raise the medullary interstitial concentration of and
This requires alkalinization of the medullary interstitium. In a patient with hypokalemia, the H+/K+-ATPase activity in the MCD is increased. The net effect of this H+ ion secretion into the lumen of the MCD is the addition of K+ and ions to the interstitial compartment (Figure 4-9). As a result, the pH in this compartment rises, converting to anions, which precipitates with ionized calcium. The rise in pH, however, is too small to raise the concentration of appreciably. Notwithstanding, although the pK for carbonate is also very high (∼10), there is a large pool of bicarbonate, the precursor for carbonate. Hence, precipitation of calcium carbonate may provide a nidus for the precipitation of calcium phosphate.