Question

How
negative
T-cell selection
Takes place in thymus?​

Answer 1

Answer:

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Explanation:

Negative selection occurs when double positive T cells bind to bone-marrow derived APC (macrophages and dendritic cells) expressing Class I or Class II MHC plus self peptides with a high enough affinity to receive an apoptosis signal. They had no hematopoietic cells but did have functional thymic stroma.