Question

How non selective Nsaid is commonly associated with peptic ulcer​

Answer 1

Answer:

Peptic ulcer disease is a well-recognised complication of NSAID use. Inhibition of COX-1 in the gastrointestinal tract leads to a reduction of prostaglandin secretion and its cytoprotective effects in gastric mucosa. This therefore increases the susceptibility to mucosal injury.

Answer 2

Answer:

by blocking the cox-1 enzyme and disrupting the production of prostaglandins in the stomach, Nsaids can couse ulcers and bleeding. Some Nsaids have less affect on prostaglandins in the stomach than others , and, therefore, may have a lower risk of causing ulcers, but the increased risk of ulcers still exists.

Explanation:

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