How phenoxybenzamine produces positive ionotropic effect?
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It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. ... Phenoxybenzamine producesits therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels.
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When phenoxybenzamine was administered into the cannulated sinus node artery, positive chronotropic and inotropic responses were induced in doses of 10-300 microgram. ... E-643 usually produced only negative chronotropic and inotropic effects.
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