How plasmid is integrated into genome after delivery?
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Explanation:
Plasmid vectors have been widely used for DNA vaccines and gene therapy. Following intramuscular injection, the plasmid that persists is extrachromosomal and integration into host DNA, if it occurs at all, is negligible. However, new technologies for improving DNA delivery could increase the frequency of integration.
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Answer:
Depends. Some plasmids are constructed to introduce part of it (mostly based on recombinases and site specific recombination). Other wise entire plasmid is integrated. Plasmid ORI (Procaryotic has no role in replication.
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