how the biosynthesis of purine and pyrimidines regulated?
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The regulation of pyrimidine synthesis occurs mainly at the first step which is catalyzed by the trifunctional enzyme encoded by the CAD gene. The ATCase activity of the enzyme is inhibited by CTP and activated by ATP. ... ATP levels also regulate pyrimidine nucleotide biosynthesis at the level of PRPP formation.
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The regulation of pyrimidine synthesis occurs mainly at the first step which is catalyzed by the trifunctional enzyme encoded by the CAD gene. The ATCase activity of the enzyme is inhibited by CTP and activated by ATP. ... ATP levels also regulate pyrimidine nucleotide biosynthesis at the level of PRPP formation.
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