how the discoveries by Rosalind Franklin helped Watson and Crick build an accurate model of DNA.
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Answer:
Hi Mate,
Explanation:
In 1951, Franklin was offered a 3-year research scholarship at King's College in London. With her knowledge, Franklin was to set up and improve the X-ray crystallography unit at King's College. Maurice Wilkins was already using X-ray crystallography to try to solve the DNA problem at King's College. Franklin arrived while Wilkins was away and on his return, Wilkins assumed that she was hired to be his assistant. It was a bad start to a relationship that never got any better.
Working with a student, Raymond Gosling, Franklin was able to get two sets of high-resolution photos of crystallized DNA fibers. She used two different fibers of DNA, one more highly hydrated than the other. From this she deduced the basic dimensions of DNA strands, and that the phosphates were on the outside of what was probably a helical structure.
She presented her data at a lecture in King's College at which James Watson was in attendance. In his book The Double Helix, Watson admitted to not paying attention at Franklin's talk and not being able to fully describe the lecture and the results to Francis Crick. Watson and Crick were at the Cavendish Laboratory and had been working on solving the DNA structure. Franklin did not know Watson and Crick as well as Wilkins did and never truly collaborated with them. It was Wilkins who showed Watson and Crick the X-ray data Franklin obtained. The data confirmed the 3-D structure that Watson and Crick had theorized for DNA. In 1953, both Wilkins and Franklin published papers on their X-ray data in the same Nature issue with Watson and Crick's paper on the structure of DNA.
Franklin left Cambridge in 1953 and went to the Birkbeck lab to work on the structure of tobacco mosaic virus. She published a number of papers on the subject and she actually did a lot of the work while suffering from cancer. She died from cancer in 1958.
In 1962, the Nobel Prize in Physiology or Medicine was awarded to James Watson, Francis Crick, and Maurice Wilkins for solving the structure of DNA. The Nobel committee does not give posthumous prizes.
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