How to about esophagus,colon,stomach,pancreatic and lungs cancer?
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We present here the rare clinical case of a 44-year-old gentleman with metastasis from colon carcinoma to the esophagus presenting with multiple nodules and dysphagia, which was successfully managed with systemic chemotherapy. The patient presented at our institution with 3-month history of dysphagia almost 4 years after being operated for stage III carcinoma in the sigmoid colon. Endoscopic findings showed multiple nodules at the gastroesophageal junction and mid esophagus. Histological features and immunostains confirmed the diagnosis of metastatic colon carcinoma. Because of evidence of extensive metastatic disease in the spine and liver requiring systemic therapy, the patient was treated with chemotherapy with irinotecan and cetuximab, with subsequent improvement in tumor markers, liver metastasis and symptoms of dysphagia. Even though repeat endoscopy showed no improvement in esophageal nodules, the overall response to chemotherapy was positive. In conclusion, we present a very rare, previously unreported case of metastases from colon cancer to the esophagus presenting as non-obstructive nodules and dysphagia that responded to systemic chemotherapy.
Case Report
We present a 44-year-old gentleman who experienced a change in bowel habits and felt a mass in the lower abdomen sometime in 2007. On colonoscopy, he was found to have malignant colon cancer in the sigmoid colon, which was surgically excised. He had 15 positive lymph nodes out of 18. With a stage III colon cancer diagnosis, he was started on adjuvant chemotherapy with leucovorin, 5-fluorouracil, oxaliplatin and bevacizumab. Unfortunately, after one cycle, the patient became extremely sick and decided not to pursue any further treatments.
I hope u can understand about your question.
We present here the rare clinical case of a 44-year-old gentleman with metastasis from colon carcinoma to the esophagus presenting with multiple nodules and dysphagia, which was successfully managed with systemic chemotherapy. The patient presented at our institution with 3-month history of dysphagia almost 4 years after being operated for stage III carcinoma in the sigmoid colon. Endoscopic findings showed multiple nodules at the gastroesophageal junction and mid esophagus. Histological features and immunostains confirmed the diagnosis of metastatic colon carcinoma. Because of evidence of extensive metastatic disease in the spine and liver requiring systemic therapy, the patient was treated with chemotherapy with irinotecan and cetuximab, with subsequent improvement in tumor markers, liver metastasis and symptoms of dysphagia. Even though repeat endoscopy showed no improvement in esophageal nodules, the overall response to chemotherapy was positive. In conclusion, we present a very rare, previously unreported case of metastases from colon cancer to the esophagus presenting as non-obstructive nodules and dysphagia that responded to systemic chemotherapy.
Case Report
We present a 44-year-old gentleman who experienced a change in bowel habits and felt a mass in the lower abdomen sometime in 2007. On colonoscopy, he was found to have malignant colon cancer in the sigmoid colon, which was surgically excised. He had 15 positive lymph nodes out of 18. With a stage III colon cancer diagnosis, he was started on adjuvant chemotherapy with leucovorin, 5-fluorouracil, oxaliplatin and bevacizumab. Unfortunately, after one cycle, the patient became extremely sick and decided not to pursue any further treatments.
I hope u can understand about your question.
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