Chemistry, asked by naricassa507, 1 year ago

How to construct protein dimer from amino acid sequence?

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Answered by snakeeye86

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Answer:

I have a protein sequence whose str is to be predicted. This protein is a homodimer, what is the best way to model its dimer:

I have a protein sequence whose str is to be predicted. This protein is a homodimer, what is the best way to model its dimer:1. Shall I use Modeller software for homology modeling to make its dimer directly based upon its template that as homodimer? If yes, shall I go for dynamic study of this dimer?

I have a protein sequence whose str is to be predicted. This protein is a homodimer, what is the best way to model its dimer:1. Shall I use Modeller software for homology modeling to make its dimer directly based upon its template that as homodimer? If yes, shall I go for dynamic study of this dimer?OR

I have a protein sequence whose str is to be predicted. This protein is a homodimer, what is the best way to model its dimer:1. Shall I use Modeller software for homology modeling to make its dimer directly based upon its template that as homodimer? If yes, shall I go for dynamic study of this dimer?OR2. shall I go for homology modeling of one subunit using Modeller and then for docking by providing this homology model to make the dimer?

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