How to crystallize out reaction mixture from DMF?
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You might be able to dissolve the compound in a mixture of solvents. I have had luck using a combination of dichloromethane and ethanol (or methanol) to dissolve similar compounds. A ternary mixture of toluene, dcm and ethanol may also work (toluene will interfere with pi-stacking interactions, while the alcohol breaks up hydrogen bonding interactions). One possible advantage with the dcm/ethanol mixture is that slow evaporation of the dcm may produce crystals (if the compound is insoluble in ethanol alone)
Whether the compound is soluble in one of these mixed solvents, or whether you need to use dmf or dmso, if you can find a miscible antisolvent, diffusion crystallization might be the best way to proceed. This will be much easier for a toluene/dcm/ethanol mix (something like diethyl ether or pentane should work nicely as an antisolvent). For dmf or dmso, I might recommend cyclohexane, dioxane or ethyl acetate...
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⬇️HERE IS YOUR ANSWER⬇️
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You might be able to dissolve the compound in a mixture of solvents. I have had luck using a combination of dichloromethane and ethanol (or methanol) to dissolve similar compounds. A ternary mixture of toluene, dcm and ethanol may also work (toluene will interfere with pi-stacking interactions, while the alcohol breaks up hydrogen bonding interactions). One possible advantage with the dcm/ethanol mixture is that slow evaporation of the dcm may produce crystals (if the compound is insoluble in ethanol alone)
Whether the compound is soluble in one of these mixed solvents, or whether you need to use dmf or dmso, if you can find a miscible antisolvent, diffusion crystallization might be the best way to proceed. This will be much easier for a toluene/dcm/ethanol mix (something like diethyl ether or pentane should work nicely as an antisolvent). For dmf or dmso, I might recommend cyclohexane, dioxane or ethyl acetate...
HOPE THIS ANSWER HELPS YOU
MARK AS BRAINLIEST ✌✌
_______×××××_______
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