How to dissolve naproxen in water and methonal?
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hello ....
Indeed, some pharmaceuticals are very hard to dissolve in water. According to literature the water solubility of Naproxen is around. +/-15 mg/l. For compounds with only a poor solubility in water, our lab has adopted following procedure:
- weigh approximately 45 mg of Naproxen (+/- 3 times the required amount for making a saturated solution)
- transfer the compound into known volume (1L) of deionized water
- stirr the solution for approximately 6 hours
- filtrate the solution.
After finishing this procedure you will have a saturated Naproxen solution (concentration +/- 15 mg/l) which can be further diluted to your desired final concentration
hope it helps u...
Indeed, some pharmaceuticals are very hard to dissolve in water. According to literature the water solubility of Naproxen is around. +/-15 mg/l. For compounds with only a poor solubility in water, our lab has adopted following procedure:
- weigh approximately 45 mg of Naproxen (+/- 3 times the required amount for making a saturated solution)
- transfer the compound into known volume (1L) of deionized water
- stirr the solution for approximately 6 hours
- filtrate the solution.
After finishing this procedure you will have a saturated Naproxen solution (concentration +/- 15 mg/l) which can be further diluted to your desired final concentration
hope it helps u...
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