How to find recombination frequency
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The term "frequency" can refer to either absolute frequency or relative frequency. Review the definitions of relative and absolute frequencies in sections 1.1 through 1.3 of the statistics manual.
Linkage analysis of this type was first performed by Bridges and Olbrycht (1926). Using the notation above, they pointed out that +mf and w++ phenotypes represent single cross-overs between w and m and that ++f and wm+ phenotypes represent single cross-overs between m and f. It must be remembered, however, that double cross-overs also represent recombination events both between w and m, and between m and f. These cases must be included when calculating either of the recombination frequencies. Therefore, the frequency of crossing-over between w and m is equal to the sum of the relative frequencies of single and double crossover outcomes:
(+mf) + (w++) + (+m+) + (w+f) or (+mf) + (w++) + (+m+) + (w+f)
total of all flies total total total total of all flies
where each value in parentheses is the absolute frequency (count) of flies in the category. Likewise, the frequency crossing-over between m and f is equal to:
(wm+) + (++f) + (+m+) + (w+f) or (wm+) + (++f) + (+m+) + (w+f)
total total total total total of all flies
So far, we have referred to these calculated values as recombination frequencies.
Linkage analysis of this type was first performed by Bridges and Olbrycht (1926). Using the notation above, they pointed out that +mf and w++ phenotypes represent single cross-overs between w and m and that ++f and wm+ phenotypes represent single cross-overs between m and f. It must be remembered, however, that double cross-overs also represent recombination events both between w and m, and between m and f. These cases must be included when calculating either of the recombination frequencies. Therefore, the frequency of crossing-over between w and m is equal to the sum of the relative frequencies of single and double crossover outcomes:
(+mf) + (w++) + (+m+) + (w+f) or (+mf) + (w++) + (+m+) + (w+f)
total of all flies total total total total of all flies
where each value in parentheses is the absolute frequency (count) of flies in the category. Likewise, the frequency crossing-over between m and f is equal to:
(wm+) + (++f) + (+m+) + (w+f) or (wm+) + (++f) + (+m+) + (w+f)
total total total total total of all flies
So far, we have referred to these calculated values as recombination frequencies.
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Answer:
Recombination frequency= No. Of recombinants ÷No. Of individuals × 100
Explanation: a pair of genes with larger recombination frequency are likely farther apart .
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