How to lower the amino acid 3-methylhistidine in blood?
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3-Methylhistidine
3-Methylhistidine is an analog of histidine found mainly in skeletal muscle. Methylation of histidine occurs after its incorporation into the peptide chains of actin and myosin. Since, after the catabolism of these proteins, 3-methylhistidine is not recycled but quantitatively excreted in the urine, it has been proposed as an index of muscle protein turnover. It has also been used to determine the meat content of foods, where vegetable or microbial protein has been added for economic or fraudulent reasons. 3-Methylhistidine may be estimated after derivatization with fluorescamine. Histidine and 3-methylhistidine give acid-stable fluorescent derivatives, which can be separated by RPC in 20 min.
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