Question

How to raise temperature in your body with an injection?

Answer 1

Changesintemperatureweredeterminedfollowinginjectionofnoradrenaline,adrenaline,isoprenaline,dopamineand5-hydroxytrypta-mine(5-HT)intothecerebralventriclesoftheconsciousmouse.2.Noradrenaline(1-20,g)anddopamine(10-160,tg)causedfallsinbodytemperature.Adrenaline(1-20,tg)causedaslightandtransientriseinbodytemperaturefollowedbyafall.Isoprenaline(5-20,g)causedariseinbodytemperature,hypothermiaonlyoccurringafterveryhighdoses(200jig)ofthiscatecholamine.3.a-and,-adrenergicblockingagents,phentolamine(>2jig)andpropranolol(>5,tg)respectively,causedfallsinbodytemperaturewheninjectedintothecerebralventriclesofthemouse.4.Specificdrugantagonismstudieswerelimitedowingtotheintrinsiceffectsoftheac-andf,-adrenergicblockingagents.However,someevidencewasobtainedtoindicatethatnoradrenalinemediateditseffectsthroughacentralac-typeadrenergicreceptor.5.5-HT(10-160,g)causedafallinbodytemperature.Theactionofthisindoleamineandthecatecholaminesinregardtothermoregulatoryfunctionisdiscussed.INTRODUCTIONThetemperaturechangesproducedbynoradrenalineand5-HTwheninjectedintothecerebralventriclesaredependentonthespeciesused.Forexample,noradrenalinelowersand5-HTraisesbodytemperatureinthecat(Feldberg&Myers,1964)anddog(Feldberg,Hellon&Myers,1966)butoppositeeffectsoccurintherabbit(Cooper,Cranston&Honour,1965)andthesheep(Bligh,1966).Intherat,5-HTcausesafallintempera-tureasdoesnoradrenaline,butwiththelatteraminethefallmaybefollowedbyaslightrise(Feldberg&Lotti,1967).Inthemouse,nor-adrenalinecausesafallintemperature(Brittain,1966).