Question

How will you convert amide into acetamide​

Answer 1

Answer:

acetate;2 by heating ammonium acetate in a sealed tube and distilling the product;3 by treating acetic anhydride with ammonia;4

Explanation:

Acetamide can be prepared by the rapid distillation of ammonium acetate;2 by heating ammonium acetate in a sealed tube and distilling the product;3 by treating acetic anhydride with ammonia;4 by heating a mixture of ammonium chloride and sodium acetate to 240°;5 by the action of cold aqueous ammonia on ethyl acetate;6 ...

Answer 2

Answer:

Extra Info => Acetamide, also known as ethanamid or acetic acid amide, belongs to the class of organic compounds known as carboximidic acids. These are organic acids with the general formula RC(=N)-OH (R=H, organic group).

Your Answer => Synthesis of Amides

There are five synthetic routes to produce amides: nitrile conversion and the acyl nucleophilic substitution reactions of acid halides, acid anhydrides, and carboxylic acids.

Nitriles can be converted to amides. This reaction can be acid or base catalyzed

Carboxylic acid can be converted to amides by using DCC as an activating agent

Direct conversion of a carboxylic acid to an amide by reaction with an amine.

Acid chlorides react with ammonia, 1o amines and 2o amines to form amides.

Acid Anhydrides react with ammonia, 1o amines and 2o amines to form amides.

Hydrolysis of Amides

Hydrolysis under acidic conditions

Taking acetamide (ethanamide) as a typical amide. If acetamide is heated with a dilute acid (such as dilute hydrochloric acid), acetic acid is formed together with ammonium ions. So, if you were using hydrochloric acid, the final solution would contain ammonium chloride and acetic acid.

Hydrolysis under alkaline conditions

Also, if acetamide is heated with sodium hydroxide solution, ammonia gas is given off and you are left with a solution containing sodium acetate.

Peptide hydrolysis

Peptide hydrolysis of proteins is amide hydrolysis. What biologists and biochemists call a peptide link (in proteins, for example) is what chemists call an amide link. Apply either hydrolysis reaction above to the dipeptide below to produce two amino acids. The amines in the products are shown in their protonated form because this hydrolysis reaction was performed under acidic conditions.

Reduction of Amides into Amines

Amides can be converted to 1°, 2° or 3° amines using LiAlH4 followed by an aqueous work-up. Alkyl groups attached to the amide nitrogen do not affect the reaction.