Question

how will you synthesize propane by Corey house reaction.Write the chemical reaction and mechanism. ​

Answer 1

Answer:

Corey-House Synthesis

Alkyl halides react with lithium in dry ether to form alkyl lithium. This alkyllithium reacts with CuI to give Dialkyl Lithium Cuprate known as Gilman reagent. This dialkyl lithium cuprate reacts with alkyl halide to give alkane and the reaction is known as Corey-House synthesis.

Answer 2

Answer:

• The versatile method of coupling reaction by joining two alkyl groups together to produce higher alkanes is known as Corey-House Reaction. This is an organic reaction that involves the reaction of R₂CuLi (a lithium divinylcuprate) to form a new alkane with an unknown organocopper compound and an organyl (pseudo) halide (RX). This reaction is limited to only primary alkyl halides but the alkyl groups in the Gilman reagent can be primary, secondary, or tertiary. Gilman reagent is Dialkyl Lithium Cuprate. This reaction is also known as Corey–Posner–Whitesides–House reaction.
• The chemical reactions and mechanism of the synthesis of propane via Corey House reaction are -

1. CH₃-X + 2Li ⇾ CH₃-Li + LiX
2. 2CH₃-Li + CuI ⇾ (CH₃)₂CuLi + LiI
3. (CH₃)₂CuLi + C₂H₆’-X ⇾ CH₃-C₂H₆’ + CH₃-Cu + LiX

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