Question

I had it on my PSA:At this age he is tired _______ his life.(a) with(b) from(c) of(d) upon

Answer 1

At this age he is tired of his life.


additionally I can tell you :
     he is retired from his ....
     he is fed up with his ...
     he is angry upon his ...

Answer 2

the answer is
at this age he is tired of his life