Identification of capsid mutations that alter the rate of hiv-1 uncoating in infected cells
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To further examine the connection between HIV-1 capsid stability and ... We propose that while proper HIV-1 uncoating in target cells is ...
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Two viral factors that have been shown to influence uncoating are the p24CA protein and the process of reverse transcription. Mutations in p24CA can alter capsid stability and decrease infectivity, indicating that overall capsid stability is important for optimal viral replication (1,–5).
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