Question

Identification of lrrc8 heteromers as an essential component of the volume-regulated anion channel vrac

Answer 1

ne flux and regulatory volume decrease also depended on LRRC8 proteins. Our work shows that VRAC defines a class of anion channels, suggests that VRAC is identical to the volume-sensitive organic osmolyte/anion channel VSOAC, and explains the heterogeneity of native VRAC currents.