Question

If a drug is having lipophilic nature will it be dissolve in aqueous pahse

Answer 1

When the salt of a weak acid dissolves in the stomach, it generates a diffusion layer of relatively high pH which,in turn, promotes further ...

the difference between lipophilic and hydrophilic

Lipophilic means affinity for fatty tissues. Hydrophilic means it likes water. Lipophilicity and hydrophilicityrefer to the solubility of something in lipids or water. Lipophilic substances tend to be non-polar, and hydrophilicsubstances tend to be polar.

Answer 2

For compounds with ionizable groups, the distribution of species is impacted by pH. ... Generally speaking, more lipophilic compounds are less soluble in aqueous media. However, lipophilic compounds may have good solubility in oils and lipids; therefore, they can be good candidates for lipid-based formulations.