Question

If cromatin is break what will effect on cell division

Answer 1

Chromatin serves as a platform for numerous cellular signals to influence gene expression. Post-translational modifications (PTMs) of histone proteins or covalent modifications of nucleotides influence a cell’s transcriptional program, which ultimately impacts cellular behavior and cell fate. Chromatin modifications are converted into transcriptional instructions by the interplay of modification “writers,” “erasers” and “readers” residing, often together, in a multitude of chromatin remodeling complexes that interact directly or indirectly with transcription factor complexes (Jenuwein and Allis, 2001). Like transcription factor complexes, the components of chromatin remodeling complexes may change with the differentiation status or fate of cells. For example lineage-specific chromatin remodeling complexes have been identified, as well as stem-cell specific complexes with functions in maintaining pluripotency (reviewed in Hargreaves and Crabtree, 2011).