If the proteases such as pepsin and trypsin, digest protein, why don't they digest the stomach and small intestine, since the stomach and small intestine are both made from protein?
Answers
They don’t digest as they are having a lining called mucus which protects them from the action of enzymes under normal conditions
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hi mate,
===>>Pepsin is secreted as pepsinogen in stomach and converted into active pepsin by HCl present in gastric juice. HCl and pepsin both could be corrosive on stomach lining: but to prevent that a thick layer of mucus keeps the stomach lining covered all the time.
===>>Stomach juice is secreted regularly during the meal time; hence if one skips a meal chances of damage to the stomach wall goes up. Action of pepsin on gut wall causes ulcer.
===>>Trypsin is secreted as inactive trypsinogen from pancreatic tissue. Once it reaches small intestine, it is converted in active trypsin by enterokinase enzyme.
===>>Trypsin acts in alkaline medium and it is prevented from taking any damaging action on intestinal lining of lumen due to presence of protective mucus layer on it.
i hope it helps you.