Impact of iron deficicency anemia on chronic periodontitis and superoxide dismutase activity
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Purpose: Both chronic periodontitis (CP) and iron deficiency anemia (IDA) induce oxidative
stress in the body and cause an imbalance between reactive oxygen species and antioxidants,
such as superoxide dismutase (SOD). This study explored the SOD enzyme activity of
saliva and serum in CP patients with and without IDA and analyzed the impact of IDA on CP.
Methods: A total of 82 patients were divided into four groups: control group (CG, 22), periodontally
healthy IDA patients (IDA-PH, 20), CP patients (CP, 20), and IDA patients with CP
(IDA-CP, 20). After clinical measurements and samplings, serum and salivary SOD levels were
determined using an SOD assay kit.
Results: IDA-CP patients exhibited a higher gingival index, bleeding on probing, probing
pocket depth, and percentage (%) of sites with a clinical attachment loss (CAL) of ≥6 mm
(P<0.008) than CP patients. The mean salivary and serum SOD levels were significantly lower
in the