importance of some adipokines and oxidative stress biomarkers in septic patients
Answers
Considerable changes occur in adipokines’ behaviour following critical illness.
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Lower adiponectin at admission with gradual consequent increase might be a useful pattern in determining better outcomes.
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Some clinical studies have suggested the adverse effects of elevated resistin and potential prognostic value of visfatin.
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Experimental studies have proposed the therapeutic value of ghrelin in critical care.
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High ADMA levels and low arginine: ADMA ratio were suggested as predictors of ICU mortality and morbidities.
Answer:
Generation of reactive oxygen species(ROS) is inevitable for aerobic organisms and in healthy cells ocurrs at
a controlled rate under conditions of oxidative stress ROS production is
dramatically increased in subsequent
alteration of membrane lipids proteins
and nucleic acid oxidation damage
of these biomolecules is associated
with again as well as a variety of pathological event including atherosclerosis carcinogenesis ischemic reperfusion injury and
neurodegenerative disorders