Question

Importance of thermal technology in preformulation

Answer 1

Thermal method of analysis are group of techniques in which changes in physical and /or chemical properties of a substance are measured as a function of temperature, while substance is subjected to controlled temperature programmes.[1]Thermal analysis and calorimetric methods have demonstrated a wide array of applications in the Preformulation, and formulation development. These techniques are critical in physical–chemical screening of early discovery leads, during salt form screening, and in the characterization of polymorphs to determine the thermodynamic relationships between the various crystal forms.[2]