Question

in A DNA length 375A^o what is the total angle covered​

Answer 1

Answer:

Ans. The first level of organization of a eukaryotic genome consists of a multifaceted and highly dynamic nucleoprotein complex known as the nucleosome. The nucleosome consists of an octamer of core histone proteins (two copies each of H2A, H2B, H3 and H4) wrapped ~1.65 times by 147 base pairs (bp) of DNA (Luger et al. 1997). A linker histone (e.g. H1 and H5) bound to a single nucleosome is known as a chromatosome. Linker histones associate with DNA located at the entry/exit sites of the nucleosome and influence the orientation of linker DNA with respect to the nucleosome (Hamiche et al. 1996; Simpson 1978; Syed et al. 2010). Typically, linker DNA describes the non-nucleosomal DNA connecting two or more nucleosomes in an array. Linker DNA length ranges between ~20–90 bp and varies among different species, tissues, and even fluctuates within a single cellular genome (van Holde 1988). In low salt, arrays of nucleosomes connected by linker DNA have the appearance of ‘beads on a string’ by electron microscopy, and form an extended primary structure that is 10 nm in diameter (10 nm fiber) (Olins and Olins 1974; van Holde 1988). Although electron microscopy (EM) has visualized 10 nm fibers using both endogenous and reconstituted chromatin, this conformation does not represent the most favored conformation under physiological conditions (Hansen 2002; Horowitz-Scherer and Woodcock 2006; Thoma et al. 1979). In the presence of physiological salt, linear chromatin condenses into a helical rearrangement of nucleosomes, referred to as chromatin folding, or formation of chromatin secondary structure (Woodcock and Dimitrov 2001).

Explanation:

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