In a lab experiment, some volunteers are given dose of antibiotics and itsconcentration in their blood is measured (in suitable units) at one hour intervals.Consider the data below:Time (hours) 0 1 2 3 Concentration 2.4 4.3 5.0 6.9Time (hours) 4 5 6 Concentration 9.1 11.4 13.5It is believed that a linear relationship exists between these variables. Estimate theline of best fit in this scenario.What will be the concentration post 3.5 hours? Also find out how long will it takefor concentration to reach 8 units?
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Answer:
Pharmacokineticsis the science of the kinetics of drug absorption, distribution, and elimination (i.e., metabolism and excretion). Kineticsis the study of the rate of a process and the factors affecting on it. The rate of a process is the change in velocity or speed with (in relation to) time.
Usually, pharmacokinetics study involves considering both experimental and theoretical approaches. The former involves development of biologic sampling techniques, analytical methods for drugs and their metabolites measurement, and procedures that help in data collection and handling, while the latter approach of pharmacokinetics involves development of pharmacokinetic models that facilitate prediction of drug disposition after drug administration [1].
For the processes of drug absorption, distribution, and elimination, there is a rate that governs each process. The rate is the change in concentration with time and is given by ± dC/dt.
According to the law of mass action, the rate of a chemical reaction (or a kinetic process) is proportional to the products of the molar concentration of the reactants each raised to a power equal to the number of molecules of substances undergoing reaction (process).