Question

In addition to mineralization involving calcium and phosphorus, what other physiological mechanisms determine the stability of bone?

Answer 1

Bone serves three main physiological functions. ... At the cel- lular level, bone matrix formation and mineralisation are mediated by osteoblasts and bone resorption is mediated by osteoclasts, while at the molecular level, a range of systemic and local factors regulate cellular and tissue level processes in bone.

Answer 2

BONE MODELLING

Bone development leads to the formation of a body scaffold. It involves series of synchronous events from early fetal stages and shows significant changes over the course of the lifespan.

PROCESS OF MODELLING

• The process of skeletal changes is known as Bone Remodeling and is characterized by - Resorption and Deposition or Mineralisation

• These processes are done primarily by Osteocyte, Osteoblast, and Osteoclast cells.
• These cells are facilitated physiologically by the signaling mechanism of the hormones in the body.

1. RESORPTION - Initially, bones are soft and require calcification at the ossification centers.

• After calcification, Osteoprogenitor cells deposit bone on the calcified cartilages.
• Subsequently, the early bone is replaced by the lamellar bone.

2. DEPOSITION - Bones grow in length by deposition of minerals on the bone matrix.

• Osteocyte cells proliferate, differentiate, and deposit the minerals.

Re-modeling continues throughout life to repair bone and maintain its shape by the addition of bone material at the periosteum sites.