Question

• In Bischler-Napieralski synthesis, which product is formed?​

Answer 1

Answer:

Bischler-Napieralski Cyclization. The Bischler-Napieralski Reaction allows the synthesis of 3,4-dihydroisoquinolines from the β-ethylamides of electron-rich arenes using condensation reagents such as P2O5, POCl3 or ZnCl2.

Answer 2

In Bischler-Napieralski synthesis, 3,4-dihydroisoquinolines is formed

Explanation:

• The Bischler-Napieralski Reaction uses condensation reagents to synthesise 3,4-dihydroisoquinolines from -ethylamides of electron-rich arenes.
• Fodor was able to make stable imidoyl salts at ambient temperature that produced nitrilium salts following mild heating, whereas the Bischler-Napieralski Reaction needed high temperatures to produce dihydroisoquinolines.
• As will be discussed later, a process involving nitrilium salts accounts for the appearance of styrenes as byproducts.