In medicine, the science of ……………. Reached new heights. *
Answers
Answer:
Pharmacology reached new heights on Hamm’s watch
“Vanderbilt’s Pharmacology Department has been excellent for many years and top-ranked among pharmacology departments nationwide,” said Hamm, the Aileen M. Lange and Annie Mary Lyle Professor of Cardiovascular Research, who was recruited from Northwestern University in 2000.
“It’s been a great privilege to build on this solid foundation (and) to recruit a number of excellent scientists who have enhanced its reputation even further,” she said. “The department has increased by every possible metric you could place on it.”
It is consistently ranked by the National Institutes of Health (NIH) as one of the top two pharmacology departments in the country, along with the University of Pennsylvania.
“Dr. Hamm has provided excellent leadership in research and education for the department and the medical school, and has contributed to Vanderbilt’s reputation as a national leader in scientific discovery, “ said Susan Wente, Ph.D., associate vice chancellor for Research and senior associate dean for Biomedical Sciences. “Heidi’s dedication to our missions has been remarkable. We are in her debt for these accomplishments and wish her well in the next era of her career with increased academic focus.”
“I also want to express my gratitude to Dr. Barnett for serving as acting chair. We are grateful for his steady leadership during this period of transition,” Balser said.
One of her priorities as chair was to recruit specialists in structural biology and membrane protein crystallography. “If you think about understanding molecules and designing drugs to work on those molecules, structural biology is going to be key,” Hamm said.
Hamm also played a key role in developing Vanderbilt’s drug discovery program by recruiting scientists from the pharmaceutical industry. As a result, “the Pharmacology Department has become known as being the place for academic drug discovery, and a place where it actually works and works repeatedly,” she said.
“Without Heidi’s vision, I don’t think it could have been done,” said one of the first recruits, P. Jeffrey Conn, Ph.D., now Lee E. Limbird Professor of Pharmacology and director of the Vanderbilt Center for Neuroscience Drug Discovery (VCNDD).
“Dr. Hamm is a good judge of scientific talent and very supportive of them as well,” added Lawrence Marnett, Ph.D., Mary Geddes Stahlman Professor of Cancer Research and director of the Vanderbilt Institute of Chemical Biology, who has worked across the institution in recruiting drug discovery scientists.
Hamm is known internationally for her elegant dissection of G protein structure and receptor activation research and how these biological “switches” are “turned on” to mediate downstream effects.
She also discovered that G protein beta gamma subunits directly inhibit secretion by binding to the exocytotic machinery, an important discovery whose significance is still being investigated.
Her “bench-to-bedside” research on the role of protease activated receptors in hemostasis and thrombosis provided insights into why people with diabetes are more susceptible to heart disease, and her laboratory has generated potent antagonists of one of these receptors.
“While her scientific accomplishments are many, I think her recent work on both PAR4 inhibitors and on small molecule protein-protein inhibitors of the beta-gamma-SNARE complex will have a major impact on both the basic pharmacology of these targets and in translation to novel therapeutics,” said Craig Lindsley, Ph.D., William K. Warren, Jr. Professor of Medicine and VCNDD director of Medicinal Chemistry.
With about 200 scientific publications to her credit, Hamm’s discoveries and reputation led to continuous and significant grant funding, including her first NIH R01 individual investigator grant, received in her first year in a faculty position and which is still funded 28 years later.
She has served as president of the American Society for Biochemistry and Molecular Biology, and on The National Academies Committee on Prospering in the Global Economy of the 21st Century that produced the influential report, “Rising above the Gathering Storm.”
She has mentored 24 graduate students and 35 postdoctoral fellows and she has been actively involved in training over 200 more Ph.D. candidates. She started an advocacy group that encourages graduate students to talk to their senators and congressmen about the importance of investing in research.
Hamm credits her path in science to an “accident of fate.”
Answer:
chemical
Explanation:
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