Question

In one compartment open model, absorption rate constant can be calculated by Options 7 O Wagner nelsom method O Trapezoidal rule O Integration method O Cut and weight method​

Answer 1

Explanation:

In one compartment open model, absorption rate constant can be calculated by Options 7 O Wagner nelsom method O Trapezoidal rule O Integration method O Cut and weight method

Answer 2

Answer:

The correct answer is : Wagner Nelson method.

In one compartment open model, absorption rate constant can be calculated by Wagner Nelson method.

Explanation:

• The Wagner-Nelson approach has been used in pharmacokinetics to correctly describe the absorption kinetics of orally delivered medicines, and its dependability is unaffected by the way gastric emptying occurs.

Advantages :

i) Even if the absorption and elimination processes can be relatively similar, it is still possible to calculate ka accurately.

ii) The absorption procedure need not be of the first kind. The investigation of the absorption process can be done using this technique. I have investigated data collected after IM injection using this type of approach and discovered that two absorption phases may be adequate. There may be a quick step from the drug in solution and a more gradual step from the drug precipitated at the injection site. The technique can offer incredibly helpful details regarding how various dose forms affect absorption.

Disadvantages:

i) This method's main drawback is that you must be aware of the elimination rate constant from data gathered after intravenous delivery.

ii) The computations needed are more difficult.

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