In one study of 400 Basques, 230 were Rh+ and 170Rh-. Assuming HWE, estimate frequencies of RhD and Rhd alleles and each genotype frequency.
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Rheumatic heart disease (RHD) is the most serious complication of heart that comprises inflammatory reactions in heart valves. Many studies have demonstrated the contribution of host genetic factors in susceptibility to RHD and many cytokine gene variants have been linked with susceptibility to RHD. We sought to determine the role of genetic variants in IL-1β, STAT3, STAT5B and TLR5 genes in conferring risk of RHD in two cohorts of RHD patients.
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