Question

In sickle-cell disease, the glutamic acid (glu) at position number seven is mutated to valine (val).What change in codons corresponds to this mutation?

Answer 1

Answer:

The mutation causing sickle cell anemia is a single nucleotide substitution (A to T) in the codon for amino acid 6. The change converts a glutamic acid codon (GAG) to a valine codon (GTG). The form of hemoglobin in persons with sickle cell anemia is referred to as HbS.