Question

In some types of colon cancer, stem cells have a mutation in the APC gene. What happens if the APC gene is mutated?

Answer 1

Question:-

In some types of colon cancer, stem cells have a mutation in the APC gene. What happens if the APC gene is mutated?

Explanation:

Acquired gene mutations

Most gene mutations that lead to cancer are acquired mutations. They happen during a person’s lifetime and are not passed on to their children. These DNA changes affect only cells that come from the original mutated cell.

In most cases of colorectal cancer, the DNA mutations that lead to cancer are acquired during a person’s life rather than having been inherited. Certain risk factors probably play a role in causing these acquired mutations, but so far it’s not known what causes most of them.

There doesn’t seem to be a single genetic pathway to colorectal cancer that's the same in all cases. In many cases, the first mutation occurs in the APC gene. This leads to an increased growth of colorectal cells because of the loss of this “brake” on cell growth. Further mutations may then occur in other genes, which can lead the cells to grow and spread uncontrollably. Other genes that aren’t known yet are probably involved as well.

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