Question

In the calculation of vd do we take plasma protein bound drugs also in the plasma concentration

Answer 1

Plasma protein binding refers to the degree to which medications attach to proteins within the blood. A drug's efficiency may be affected by the degree to which it binds. The less bound a drug is, the more efficiently it can traverse cell membranes or diffuse. Common blood proteins that drugs bind to are human serum albumin, lipoprotein, glycoprotein, and α, β‚ and γ globulins.

Answer 2

Answer:

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The 'red herring' effect is caused by drug binding to plasma proteins. A higher concentration in the sample leads to a lower apparent volume of distribution. Based on total drug concentration the apparent volume of distribution will be small when there is extensive binding to plasma proteins.

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