Question

in the glucuronidation reaction of oxazepam the functional group responsible is​

Answer 1

Answer:

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Answer 2

The Answer is:

Oxazepam, a therapeutic drugs derivative of diazepam, is one of several C3-hydroxylated benzodiazepines with glucuronide conjugation as the primary biotransformation mechanism.

• Ethinylestradiol, Fenoprofen, Ibuprofen, Ketoprofen, and Naproxen are glucuronidation inhibitors in Oxazepam reactions.
• Phenobarbitone and Phenytoin are the inducers.
• Oxazepam is a short-acting benzodiazepine that is often used as an anxiolytic.
• It also metabolises "diazepam", "ketazolam", "temazepam", "chlordiazepoxide", "demoxazepam", "halazepam", "medazepam", "prazepam", "pinazepam", and "chlorazepate".
• Glucuronidation is typically caused by "drugs", "pollutants", "bilirubin", "androgens", "estrogens", "mineralocorticoids", "glucocorticoids", "fatty acid derivatives", "retinoids", and "bile acids". These are glycosidic linkages.
• Oxazepam is a benzodiazepine with a short-to-intermediate duration of action. Oxazepam is a medication used to treat anxiety and insomnia, as well as the management of alcohol withdrawal symptoms.
• It is a diazepam, prazepam, and temazepam metabolite with modest amnesic, anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant characteristics when compared to other benzodiazepines.
• It was patented in 1962 and given medical approval in 1964.

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