In which part of kidney vasopressin shows its effects?
Answers
Explanation:
The most important action of vasopressin is its antidiuretic action on the collecting ducts of the kidney. Vasopressin binds to V2 receptors on the cell surface of tubular cells, initiating an intracellular cascade which results in the generation of the water channel, aquaporin-2. Preformed aquaporin-2 also migrates and inserts into the luminal membrane of the tubule cells, where it acts a conduit for water to be reabsorbed from the urine, through the cell, and back into the circulation. This leads to a decrease in renal free water clearance, concentration of urine, and a reduction in urine volume. The net effect is the reabsorption of water into the blood, which, along with thirst-generated water intake, leads to normalization of plasma osmolality.
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