In your opinion what is the most important step in homology modeling and why? if the sequence identity is in the twilight zone which would be your method for modelling, justify your answer. What is the structure prediction basis for ab-initio method?
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Homology modeling obtains the three dimensional structure of a target protein based on the similarity between template and target sequences and this technique proves to be efficient when it comes to studying membrane proteins that are hard to crystallize like GPCR as it provides a higher degree of understanding of ..
Homology modeling predicts the 3D structure of a query protein through the sequence alignment of template proteins. Generally, the process of homology modeling involves four steps: target identification, sequence alignment, model building and model refinement (Meier and Soding, 2015).
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