Influence of molecular weight on hydrogel properties
Answers
1,4-Butanediol diglycidyl ether (BDDE) crosslinked hyaluronic acid (HA) suspended in three different HAs (697, 1058, 1368 kDa) were prepared to investigate the effect of HA molecular weight on swelling property and elastic modulus of the hydrogels. The amount of the residual BDDE after final dialysis was less than 0.5 ppm. The highest swelling ratio was observed for the uncrosslinked HA having the largest molecular weight. The expansion capacity of HA rose with increasing the amount of pure HA and was inversely proportional to the crosslinking degree due to an increased number of coiled HA chain interactions. Elastic modulus (G') of monophasic fillers having different ratios of 1.0 w/v% BDDE crosslinked HAs to pure HA (1368 kDa) were within 152 and 325 Pa. 178 Pa was observed for the biphasic fillers consisting of 15% crosslinked HA (697 kDa) nanoparticles suspended in 85% of uncrosslinked HA (1368 kDa).
1,4-Butanediol diglycidyl ether (BDDE) crosslinked hyaluronic acid (HA) suspended in three different HAs (697, 1058, 1368 kDa) were prepared to investigate the effect of HA molecular weight on swelling property and elastic modulus of the hydrogels. The amount of the residual BDDE after final dialysis was less than 0.5 ppm. The highest swelling ratio was observed for the uncrosslinked HA having the largest molecular weight. The expansion capacity of HA rose with increasing the amount of pure HA and was inversely proportional to the crosslinking degree due to an increased number of coiled HA chain interactions. Elastic modulus (G') of monophasic fillers having different ratios of 1.0 w/v% BDDE crosslinked HAs to pure HA (1368 kDa) were within 152 and 325 Pa. 178 Pa was observed for the biphasic fillers consisting of 15% crosslinked HA (697 kDa) nanoparticles suspended in 85% of uncrosslinked HA (1368 kDa).
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