Question

Inhibition of cholesterol synthesis by ()-hydroxycitrate in perfused rat liver. Evidence for an extramitochondrial mevalonate synthesis from acetyl coenzyme a

Answer 1

Explanation:

This effect is likely to result from a shortage of cytoplasmic acetyl-CoA. ... In this paper an inhibition of hepatic cholesterol and fatty acid synthesis by (-)-hydroxycitrate in the isolated perfused rat liver is reported; acetate reversed the effect on fatty acid synthesis

Answer 2

Answer:

(-)- Hydrocycitrate rather than endogenous citrate is responsible for the simatory effect. The similarity of the (-)-Hydroxycitrate effect on cholesterol and fatty acid synthesis is suggestive of a common mechanism of inhibition. e.g. Lowering of the Cytoplasmic acetyl-CoA level.